Article
A toxic shock syndrome toxin-1 peptide that shows homology to mycobacterial heat shock protein 18 is presented as conventional antigen to T cells by multiple HLA-DR alleles.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1992
Ramesh N, Spertini F, Scholl P, Geha R
Abstract excerpt
We observe that PBMC from most adults (16 of 18 subjects tested) show a small but significant in vitro proliferative response to a 30-amino acid-long peptide (peptide 2, amino acids 34-63) derived from toxic shock syndrome toxin. By contrast, PBMC from newborn blood and thymocytes do not prolifer...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Antigens, Bacterial
- Bacterial Toxins
- Enterotoxins
- HLA-DR Antigens
- Heat-Shock Proteins
- Humans
- Molecular Sequence Data
- Mycobacterium leprae
- Peptide Fragments