Article
Constitutively active protein phosphatase 1alpha causes Rb-dependent G1 arrest in human cancer cells.
Current biology : CB - 1 Jun 1997
Berndt N, Dohadwala M, Liu C W
Abstract excerpt
BACKGROUND: The retinoblastoma protein (Rb) needs to be phosphorylated by cyclin-dependent kinases (CDKs) before mammalian cells can enter the S phase of the cell cycle. As protein phosphatase 1 (PP1) activates Rb and is itself a target for inhibitory phosphorylation by CDKs in vitro, we asked whether any effects of PP1 on cell cycle progression depend on its phosphorylation and are mediated through Rb. RESULTS:...
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