Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating p53

1 Nov 2004

Abstract excerpt

Nitric oxide (NO) is a potent tumor radiosensitizer; however, its clinical use is limited by systemic side effects. We have demonstrated previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and tumors induces high-output NO production that significantly enhances tumor radioresponsiveness, with no observed side effects. Notably, iNOS gene transfer enhances tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Nitric Oxide and Endothelin Effects
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15520210
DOI: 10.1158/0008-5472.can-04-2212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating p53PMID 15520210Read ↗

Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanismSemantic proximity Read ↗

The Role of Nitric Oxide in Cancer: Master Regulator or NOt?Semantic proximity Read ↗

Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation.Semantic proximity Read ↗

Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.Semantic proximity Read ↗

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progressionSemantic proximity Read ↗

Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53Semantic proximity Read ↗

Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesisSemantic proximity Read ↗

iNOS-Selective Inhibitors For Cancer Prevention: Promise And ProgressSemantic proximity Read ↗

Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells.Semantic proximity Read ↗

Nitric oxide-mediated regulation of chemosensitivity in cancer cells.Semantic proximity Read ↗

The actions and interactions of nitric oxide in solid tumours.Semantic proximity Read ↗

ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.