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Article

Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity.

Molecular and cellular biology - 1 Jan 2008

James Melissa K, Ray Arpita, Leznova Dina, Blain Stacy W

Abstract excerpt

Whether p27 is a cyclin D-cdk4/6 inhibitor or not is controversial, and how it might switch between these two modes is unknown. Arguing for a two-state mechanism, we show that p27 bound to cyclin D-cdk4 can be both inhibitory and noninhibitory, due to its differential-growth-state-dependent tyrosine phosphorylation. We found that p27 from proliferating cells was noninhibitory but that p27 from arrested cells was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17908796
DOI: 10.1128/MCB.02171-06
PMCID: PMC2223302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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