Article
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication.
Journal of virology - 1 Jul 1997
Xu J, Mendez E, Caron P R, Lin C, Murcko M A, Collett M S, Rice C M
Abstract excerpt
Members of the Flaviviridae encode a serine proteinase termed NS3 that is responsible for processing at several sites in the viral polyproteins. In this report, we show that the NS3 proteinase of the pestivirus bovine viral diarrhea virus (BVDV) (NADL strain) is required for processing at nonstru...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Catalysis
- Cattle
- Cell Line
- Cricetinae
- Molecular Sequence Data
- Mutation
- Peptide Hydrolases
- Pestivirus
- Protein Processing, Post-Translational