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Article

Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses.

The Biochemical journal - 1 Feb 2007

Shiryaev Sergey A, Kozlov Igor A, Ratnikov Boris I, Smith Jeffrey W, Lebl Michal, Strongin Alex Y

Abstract excerpt

Regulated proteolysis of the polyprotein precursor by the NS2B-NS3 protease is required for the propagation of infectious virions. Unless the structural and functional parameters of NS2B-NS3 are precisely determined, an understanding of its functional role and the design of flaviviral inhibitors will be exceedingly difficult. Our objectives were to define the substrate recognition pattern of the NS2B-NS3 protease...

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Identifiers

PMID: 17067286
DOI: 10.1042/BJ20061136
PMCID: PMC1770841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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