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Article

Temporal Modulation of an Autoprotease Is Crucial for Replication and Pathogenicity of an RNA Virus

14 Sept 2004

Abstract excerpt

Pestiviruses belong to the family Flaviviridae, and their genome is a single-stranded RNA of positive polarity encoding one large polyprotein which is further processed into mature proteins. Noncytopathogenic (noncp) strains of the pestivirus bovine viral diarrhea virus (BVDV) can establish persistent infection. In persistently infected animals, noncp BVDVs occasionally acquire mutations in viral nonstructural...

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Identifiers

PMID: 15367643
DOI: 10.1128/jvi.78.19.10765-10775.2004

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