Article
Increased genetic stability of HeLa cells after connexin 43 gene transfection.
Cancer research - 1 Jun 1997
Zhu W, Mironov N, Yamasaki H
Abstract excerpt
To test the hypothesis that intact gap-junctional intercellular communication (GJIC) is necessary for genomic stability, we compared the spontaneous and chemically induced mutation frequencies in GJIC-proficient and -deficient HeLa cells. Thus, we determined microsatellite instability and mutation frequency in the HPRT gene in parental HeLa cells, which have no GJIC ability, and in HeLa cells in which GJIC was...
Topics
- Antimetabolites, Antineoplastic
- Cell Communication
- Cell Survival
- Cells, Cultured
- Connexin 43
- Glycyrrhetinic Acid
- HeLa Cells
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Methylnitronitrosoguanidine
- Methylnitrosourea