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Article

Restoration of gap-junctional intercellular communication in a communication-deficient rat liver cell mutant by transfection with connexin 43 cDNA.

Molecular carcinogenesis - 1 Jan 1993

Jou Y S, Matesic D, Dupont E, Lu S C, Rupp H L, Madhukar B V, Oh S Y, Trosko J E, Chang C C

Abstract excerpt

To study the biochemical basis of gap-junctional intercellular communication (GJIC) and its role in tumorigenesis, a mammalian cell expression vector carrying both a rat connexin 43 (Cx43) cDNA and an amplifiable dihydrofolate reductase (DHFR) gene was transfected into the GJIC-deficient rat liver mutant cell line aB1. Two stable transfectants were selected for further amplification of the transfected Cx43 gene...

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Identifiers

PMID: 8280372
DOI: 10.1002/mc.2940080406

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Restoration of gap-junctional intercellular communication in a communication-deficient rat liver cell mutant by transfection with connexin 43 cDNA.PMID 8280372Read ↗

Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line.Semantic proximity Read ↗

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Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice.Semantic proximity Read ↗

Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases.Semantic proximity Read ↗

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