Article
Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Oct 2009
Chen Philip E, Errington Michael L, Kneussel Matthias, Chen Guiquan, Annala Alexander J, Rudhard York H, Rast Georg F, Specht Christian G, Tigaret Cezar M, Nassar Mohammed A, Morris Richard G M, Bliss Timothy V P, Schoepfer Ralf
Abstract excerpt
The NMDA receptor (NMDAR) subunit GluN1 is an obligatory component of NMDARs without a known functional homolog and is expressed in almost every neuronal cell type. The NMDAR system is a coincidence detector with critical roles in spatial learning and synaptic plasticity. Its coincidence detection property is crucial for the induction of hippocampal long-term potentiation (LTP). We have generated a mutant mouse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.