Article
Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 1997
Dekker J W, Nizankowska E, Schmitz-Schumann M, Pile K, Bochenek G, Dyczek A, Cookson W O, Szczeklik A
Abstract excerpt
BACKGROUND: Aspirin-induced asthma (AIA) affects one in 10 individuals with adult-onset asthma. It is not known if aspirin sensitivity is due to immune mechanisms or to interference with biochemical pathways. OBJECTIVE: The study aimed to test for possible involvement of the genes of the Major Histocompatibility Complex (MHC) in AIA. METHODS: HLA-DPB1 and HLA-DRB1 genotyping was carried out by DNA methods in 59...
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