Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transient DNA relaxation in Escherichia coli induced by nalidixic acid.

Biological & pharmaceutical bulletin - 1 May 1997

Ohtsuka Y, Mizushima T, Miki T, Sekimizu K

Abstract excerpt

We report here the transient relaxation of plasmid DNA by inhibitors of DNA gyrase in Escherichia coli. Relaxation of plasmid DNA in the presence of nalidixic acid, an inhibitor of the A subunit of DNA gyrase, lasted less than 60 min. The effect of nalidixic acid was not observed in a nalA26 mutant, a strain resistant to nalidixic acid due to a mutation in the gyrA gene. Novobiocin, whose target is the B subunit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to DNA, Bacterial
Share to DNA, Superhelical

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Genes, Bacterial

Share to Heat-Shock Proteins

Share to Membrane Proteins

Share to Mutation

Source

Identifiers

PMID: 9178922
DOI: 10.1248/bpb.20.467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transient DNA relaxation in Escherichia coli induced by nalidixic acid.PMID 9178922Read ↗

DNA supercoiling in a thermotolerant mutant of Escherichia coli.Semantic proximity Read ↗

Stability of linear DNA in recA mutant Escherichia coli cells reflects ongoing chromosomal DNA degradation.Semantic proximity Read ↗

Effect of nalidixic acid on recombination and DNA repair of Escherichia coli K-12 strains.Semantic proximity Read ↗

Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli.Semantic proximity Read ↗

RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis of topoisomerase-mediated genome-wide transcriptional responses in Escherichia coli.Semantic proximity Read ↗

Influence of uvrA, recJ and recN gene mutations on nucleoid reorganization in UV-treated Escherichia coli cells.Semantic proximity Read ↗

Heat shock-induced DNA relaxation in vitro by DNA gyrase of Escherichia coli in the presence of ATP.Semantic proximity Read ↗

Expression of the recA gene is reduced in Escherichia coli topoisomerase I mutants.Semantic proximity Read ↗

Alteration of Escherichia coli topoisomerase IV to novobiocin resistance.Semantic proximity Read ↗

Filamentation promotes F'lac loss in Escherichia coli K12.Semantic proximity Read ↗

Postantibiotic effect and delay of regrowth in strains carrying mutations that save proteins or RNA.Semantic proximity Read ↗

Isolation and quantitation of topoisomerase complexes accumulated on Escherichia coli chromosomal DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.