Transient DNA relaxation in Escherichia coli induced by nalidixic acid.

doi:10.1248/bpb.20.467

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Article

Transient DNA relaxation in Escherichia coli induced by nalidixic acid.

Biological & pharmaceutical bulletin - 1 May 1997

Ohtsuka Y, Mizushima T, Miki T, Sekimizu K

Abstract excerpt

We report here the transient relaxation of plasmid DNA by inhibitors of DNA gyrase in Escherichia coli. Relaxation of plasmid DNA in the presence of nalidixic acid, an inhibitor of the A subunit of DNA gyrase, lasted less than 60 min. The effect of nalidixic acid was not observed in a nalA26 muta...

Topics

Bacterial Proteins
Chloramphenicol
DNA, Bacterial
DNA, Superhelical
Escherichia coli
Genes, Bacterial
Heat-Shock Proteins
Membrane Proteins
Mutation
Nalidixic Acid
Novobiocin
Protein Synthesis Inhibitors
Son of Sevenless Proteins
Topoisomerase II Inhibitors

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