Article
Enhanced deletion formation by aberrant DNA replication in Escherichia coli.
Genetics - 1 Jun 1997
Saveson C J, Lovett S T
Abstract excerpt
Repeated genes and sequences are prone to genetic rearrangements including deletions. We have investigated deletion formation in Escherichia coli strains mutant for various replication functions. Deletion was selected between 787 base pair tandem repeats carried either on a ColE1-derived plasmid or on the E. coli chromosome. Only mutations in functions associated with DNA Polymerase III elevated deletion rates in...
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