Article
Replication restart: a pathway for (CTG).(CAG) repeat deletion in Escherichia coli.
Mutation research - 20 Mar 2006
Kim Seung-Hwan, Pytlos Małgorzata J, Sinden Richard R
Abstract excerpt
(CTG)n.(CAG)n repeats undergo deletion at a high rate in plasmids in Escherichia coli in a process that involves RecA and RecB. In addition, DNA replication fork progression can be blocked during synthesis of (CTG)n.(CAG)n repeats. Replication forks stalled at (CTG)n.(CAG)n repeats may be rescued by replication restart that involves recombination as well as enzymes involved in replication and DNA repair, and this...
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