Article
Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion.
Breast cancer research : BCR - 1 Jan 2007
Holliday Deborah L, Hughes Simon, Shaw Jacqueline A, Walker Rosemary A, Jones J Louise
Abstract excerpt
BACKGROUND: Stromal fibroblasts can contribute to tumor invasion through the release of matrix metalloproteinases (MMPs). Population studies have suggested that single nucleotide polymorphisms (SNPs) in MMP genes influence levels of expression and may be associated with breast cancer risk and with disease progression. This study directly examined the impact of MMP SNP genotype on the ability of host fibroblasts...
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