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Roles of IGFBP-3 in cell migration and growth in an endophytic tongue squamous cell carcinoma cell line

7 Jul 2022

Abstract excerpt

Abstract Insulin-like growth factor binding protein-3 (IGFBP-3) is a member of the IGFBP family that has high affinity for IGFs and functions as either an oncogene or tumor suppressor in various types of cancer. We previously found that IGFBP3 mRNA levels are higher in endophytic-type human tongue squamous cell carcinoma (TSCC) that is more invasive and more prone to metastasis than exophytic and superficial...

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PMID: 35798794
DOI: 10.1038/s41598-022-15737-y

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