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Article

Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension.

American journal of hypertension - 1 Sept 1997

Chiang F T, Chiu K C, Tseng Y Z, Lee K C, Chuang L M

Abstract excerpt

Hypertension is a complex disease with strong genetic influences. Essential hypertension has been shown to be associated with insulin resistance. A molecular variant with G-to-A transition at the nucleotide -258 of the liver glucokinase (GCK) promoter was found in diabetic patients. The variant A allele is associated with insulin resistance. We examine the role of this genetic variant in the pathogenesis of...

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Identifiers

PMID: 9324112
DOI: 10.1016/s0895-7061(97)00281-1

Genes

GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension.PMID 9324112Read ↗

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