Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort.

The Journal of clinical endocrinology and metabolism - 1 Oct 2002

Jacobson Peter, Ukkola Olavi, Rankinen Tuomo, Snyder Eric E, Leon Arthur S, Rao D C, Skinner James S, Wilmore Jack H, Lönn Lars, Cowan George S, Sjöström Lars, Bouchard Claude

Abstract excerpt

The prevalence of mutations within and in the flanking regions of the gene encoding the melanocortin 4 receptor was investigated in severely obese and normal-weight subjects from the Swedish Obese Subjects study, the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family study, and a Memphis cohort. A total of 433 white and 95 black subjects (94% females) were screened for mutations by direct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black People

Share to Obesity

Share to Receptor, Melanocortin, Type 4

Share to Receptors, Corticotropin

Share to Sweden

Share to Tennessee

Source

Identifiers

PMID: 12364415
DOI: 10.1210/jc.2002-020568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort.PMID 12364415Read ↗

Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin.Semantic proximity Read ↗

Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population.Semantic proximity Read ↗

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.Semantic proximity Read ↗

Clinical and functional relevance of melanocortin-4 receptor variants in obese German children.Semantic proximity Read ↗

Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutation.Semantic proximity Read ↗

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.Semantic proximity Read ↗

Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis.Semantic proximity Read ↗

Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective.Semantic proximity Read ↗

Melanocortin-4 receptor gene mutations in a Dutch cohort of obese children.Semantic proximity Read ↗

Mutations in melanocortin-4 receptor and human obesity.Semantic proximity Read ↗

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.Semantic proximity Read ↗

Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.