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Article

Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin.

Diabetologia - 1 Aug 1997

Gotoda T, Scott J, Aitman T J

Abstract excerpt

Disruption of the melanocortin-4 (MC-4) receptor gene in mice results in maturity-onset obesity, hyperinsulinaemia and hyperglycaemia. These phenotypes are characteristic of human obesity that frequently accompanies non-insulin-dependent diabetes. It is therefore possible that human MC-4 receptor...

Topics

Adult
Base Sequence
Blood Glucose
Cohort Studies
DNA
Genetic Variation
Genotype
Humans
Insulin
Male
Middle Aged
Mutation
Obesity, Morbid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Receptor, Melanocortin, Type 4

Receptors, Peptide

Source

Identifiers

PMID: 9267995
DOI: 10.1007/s001250050777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9267995-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin.PMID 9267995Read ↗

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