Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced restriction site mutation (RSM) analysis of 1,2-dimethylhydrazine induced mutations, using endogenous p53 intron sequences.

Mutagenesis - 1 May 1997

Jenkins G J, de G Mitchell I, Parry J M

Abstract excerpt

The restriction site mutation (RSM) assay was used to study the mutational sensitivities of three target regions of the murine p53 gene. The non-coding intron 6 target region was compared with the coding regions exon 4 and exon 5 with respect to their relative sensitivity to the induction of mutations by 1,2-dimethylhydrazine (DMH). Our results demonstrated that the majority of induced mutations detected were in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9175635
DOI: 10.1093/mutage/12.3.117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced restriction site mutation (RSM) analysis of 1,2-dimethylhydrazine induced mutations, using endogenous p53 intron sequences.PMID 9175635Read ↗

The restriction site mutation (RSM) method: clinical applications.Semantic proximity Read ↗

The detection of mutations induced in vitro in the human p53 gene by hydrogen peroxide with the restriction site mutation (RSM) assay.Semantic proximity Read ↗

Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene.Semantic proximity Read ↗

The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event.Semantic proximity Read ↗

Development of new molecular procedures for the detection of genetic alterations in man.Semantic proximity Read ↗

Different mutation frequencies and spectra among organs by N-methyl-N-nitrosourea in rpsL (strA) transgenic mice.Semantic proximity Read ↗

Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress.Semantic proximity Read ↗

Restriction site mutation analysis, a proposed methodology for the detection and study of DNA base changes following mutagen exposure.Semantic proximity Read ↗

No change in spontaneous mutation frequency or specificity in dietary restricted mice.Semantic proximity Read ↗

Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice.Semantic proximity Read ↗

p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.Semantic proximity Read ↗

Restriction fragment pattern analysis of HPRT mutations induced in rat-liver epithelial cells by alkylating and arylating agents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.