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Article

A complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate.

Antimicrobial agents and chemotherapy - 1 Jun 1997

Sirot D, Recule C, Chaibi E B, Bret L, Croize J, Chanal-Claris C, Labia R, Sirot J

Abstract excerpt

Escherichia coli GR102 was isolated from feces of a leukemic patient. It expressed different levels of resistance to amoxicillin or ticarcillin plus clavulanate and to the various cephalosporins tested. The double-disk synergy test was weakly positive. Production of a beta-lactamase with a pI of 5.6 was transferred to E. coli HB101 by conjugation. The nucleotide sequence was determined by direct sequencing of the...

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Identifiers

PMID: 9174192
DOI: 10.1128/AAC.41.6.1322
PMCID: PMC163908

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate.PMID 9174192Read ↗

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