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Article

A complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate.

Antimicrobial agents and chemotherapy - 1 Jun 1997

Sirot D, Recule C, Chaibi E B, Bret L, Croize J, Chanal-Claris C, Labia R, Sirot J

Abstract excerpt

Escherichia coli GR102 was isolated from feces of a leukemic patient. It expressed different levels of resistance to amoxicillin or ticarcillin plus clavulanate and to the various cephalosporins tested. The double-disk synergy test was weakly positive. Production of a beta-lactamase with a pI of...

Topics

Anti-Bacterial Agents
Conjugation, Genetic
Escherichia coli
Humans
Isoelectric Focusing
Kinetics
Microbial Sensitivity Tests
Mutation
Phenotype
beta-Lactam Resistance
beta-Lactamases

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beta-Lactams

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Identifiers

PMID: 9174192
DOI: 10.1128/AAC.41.6.1322
PMCID: PMC163908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9174192-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate.PMID 9174192Read ↗

TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).Semantic proximity Read ↗

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