Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.

Antimicrobial agents and chemotherapy - 1 Dec 2004

Poirel Laurent, Mammeri Hedi, Nordmann Patrice

Abstract excerpt

Enterobacter aerogenes clinical isolate LOR was resistant to penicillins and ceftazidime but susceptible to cefuroxime, cephalothin, cefoxitin, cefotaxime, ceftriaxone, and cefepime. PCR and cloning experiments from this strain identified a novel TEM-type beta-lactamase (TEM-121) differing by five amino acid substitutions from beta-lactamase TEM-2 (Glu104Lys, Arg164Ser, Ala237Thr, Glu240Lys, and Arg244Ser) and by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Lactam Resistance
Share to beta-Lactamases
Share to Ceftazidime

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cephalosporin Resistance

Share to Cephalosporins

Share to Clavulanic Acid

Share to Isoelectric Focusing

Share to Transformation, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 15561821
DOI: 10.1128/AAC.48.12.4528-4531.2004
PMCID: PMC529203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.PMID 15561821Read ↗

TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).Semantic proximity Read ↗

A complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate.Semantic proximity Read ↗

Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.Semantic proximity Read ↗

Properties of IRT-14 (TEM-45), a newly characterized mutant of TEM-type beta-lactamases.Semantic proximity Read ↗

Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.Semantic proximity Read ↗

Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacaeSemantic proximity Read ↗

A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.Semantic proximity Read ↗

Genome characterization of a Klebsiella pneumoniae co-producing OXA-181 and KPC-121 resistant to ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam and cefiderocol isolated from a critically ill patientSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.