TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).

doi:10.1128/AAC.49.11.4443-4447.2005

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Article

TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).

Antimicrobial agents and chemotherapy - 1 Nov 2005

Robin F, Delmas J, Chanal C, Sirot D, Sirot J, Bonnet R

Abstract excerpt

Escherichia coli CF349 exhibited a complex beta-lactam resistance phenotype, including resistance to amoxicillin and ticarcillin alone and in combination with clavulanate and to some extended-spectrum cephalosporins. The double-disk synergy test was positive. CF349 harbored an 85-kb conjugative plasmid which encoded a beta-lactamase of pI 5.9. The corresponding bla gene was identified by PCR and sequencing as a...

Topics

Amino Acid Substitution
Escherichia coli
Humans
Microbial Sensitivity Tests
Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA
beta-Lactam Resistance
beta-Lactamases

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Identifiers

PMID: 16251281
DOI: 10.1128/AAC.49.11.4443-4447.2005
PMCID: PMC1280126

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