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Article

Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.

Antimicrobial agents and chemotherapy - 1 Apr 2007

Robin Frédéric, Delmas Julien, Schweitzer Cédric, Tournilhac Olivier, Lesens Olivier, Chanal Catherine, Bonnet Richard

Abstract excerpt

Two clinical isolates of Escherichia coli, CF1179 and CF1295, were isolated from a patient hospitalized in the hematology unit of the University Hospital of Clermont-Ferrand, Clermont-Ferrand, France. They were resistant to penicillin-clavulanate combinations and to ceftazidime. The double-disk synergy test was positive only for isolate CF1179. Molecular comparison of the isolates showed that they were clonally...

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Identifiers

PMID: 17220412
DOI: 10.1128/AAC.01058-06
PMCID: PMC1855492

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Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.PMID 17220412Read ↗

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A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.Semantic proximity Read ↗

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