Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes.

doi:10.1093/nar/25.12.2455

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Article

Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes.

Nucleic acids research - 15 Jun 1997

Michikawa Y, Hofhaus G, Lerman L S, Attardi G

Abstract excerpt

In the present study, a comprehensive, rapid and sensitive method for screening sequence variation of the human mitochondrial tRNA genes has been developed. For this purpose, the denaturing gradient gel electrophoresis (DGGE) technique has been appropriately modified for simultaneous mutation ana...

Topics

Cell Line
DNA, Mitochondrial
Genetic Variation
Humans
Nucleic Acid Heteroduplexes
Point Mutation
RNA
RNA, Mitochondrial
RNA, Transfer, Amino Acid-Specific
RNA, Transfer, Leu
RNA, Transfer, Lys

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