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Article

Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes.

Nucleic acids research - 15 Jun 1997

Michikawa Y, Hofhaus G, Lerman L S, Attardi G

Abstract excerpt

In the present study, a comprehensive, rapid and sensitive method for screening sequence variation of the human mitochondrial tRNA genes has been developed. For this purpose, the denaturing gradient gel electrophoresis (DGGE) technique has been appropriately modified for simultaneous mutation analysis of a large number of samples and adapted so as to circumvent the problems caused by the anomalous electrophoretic...

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Identifiers

PMID: 9171099
DOI: 10.1093/nar/25.12.2455
PMCID: PMC146751

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