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Article

Quantitative mitochondrial DNA mutation analysis by denaturing HPLC.

Clinical chemistry - 1 Jun 2007

Lim Kok Seong, Naviaux Robert K, Haas Richard H

Abstract excerpt

BACKGROUND: In recent years, denaturing HPLC (DHPLC) has been widely used to screen the whole mitochondrial genome or specific regions of the genome for DNA mutations. The quantification and mathematical modeling of DHPLC results is, however, underexplored. METHODS: We generated site-directed mutants containing some common mutations in the mitochondrial DNA (mtDNA) tRNA(leu) region with different mutation loads...

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Share to Cell Line, Tumor
Share to Chromatography, High Pressure Liquid
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heteroduplex Analysis

Share to Mutagenesis, Site-Directed

Share to Nucleic Acid Denaturation

Share to Reproducibility of Results

Share to RNA, Transfer, Amino Acyl

Source

Identifiers

PMID: 17446331
DOI: 10.1373/clinchem.2006.083303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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