Temperature-sensitive mutants of Actinobacillus pleuropneumoniae induce protection in mice.

doi:10.1128/iai.65.6.2206-2210.1997

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Article

Temperature-sensitive mutants of Actinobacillus pleuropneumoniae induce protection in mice.

Infection and immunity - 1 Jun 1997

Byrd W, Hooke A M

Abstract excerpt

Temperature-sensitive mutants of Actinobacillus pleuropneumoniae 4074, serotype 1, were isolated after treatment with nitrosoguanidine and enrichment with penicillin and D-cycloserine. Of the four temperature-sensitive mutants evaluated in mice, one (A-1) had a tight phenotype (i.e., it ceased re...

Topics

Actinobacillus pleuropneumoniae
Animals
Bacterial Vaccines
Enzyme-Linked Immunosorbent Assay
Female
Immunization
Mice
Mice, Inbred ICR
Mutation
Temperature

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