Article
Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities.
Blood - 1 Jun 1997
Oscier D G, Thompsett A, Zhu D, Stevenson F K
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is a B-cell tumor involving small lymphocytes that generally express the CD5 antigen and low levels of surface Ig. Within this definition, there is heterogeneity among cases in cell morphology, karyotypic abnormalities, and clinical course. Trisomy 12, the most...
Topics
- Aged
- Aged, 80 and over
- Amino Acid Sequence
- Chromosome Aberrations
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 13
- Female
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Leukemia, Lymphocytic, Chronic, B-Cell
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation