Article
Rapid evolution of viral RNA genomes.
The Journal of nutrition - 1 May 1997
Domingo E
Abstract excerpt
Mutation rates during RNA virus replication are several orders of magnitude larger than those operating during replication of cellular DNA. This results in the continuous generation of mutant genomes and in their rating in competition with other variants present and arising in the population. The dynamic mutant distributions that constitute RNA virus populations are termed quasispecies. This concept has...
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