Article
RNA virus evolution, population dynamics, and nutritional status.
Biological trace element research - 1 Jan 1997
Domingo E
Abstract excerpt
Trace elements exert a strong influence on immune function. Debilitated humoral and cellular immune responses may impair virus clearance in infected organisms, and favor the generation of virus variants with altered biological properties. The population size in evolving viral quasispecies, as well as increased mutagenesis triggered by oxidative stress, may contribute to altering the outcome of quasispecies...
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