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Article

Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.

Experimental biology and medicine (Maywood, N.J.) - 1 Nov 2013

Chen Yuanyuan, Cao Wenwan, Zhou Shixin, Shen Liang, Wen Jinhua

Abstract excerpt

Transcriptional factor paired box 6 (PAX6) is very important for the development of the eyes, central nervous system, and pancreas. PAX6 mutations are associated with a diabetic phenotype and abnormal glucose metabolism. Our previous study showed that PAX6 directly bound to and activated the prohormone convertase 1/3 (Pc1/3) gene promoter and subsequently regulated proinsulin processing. Prohormone convertase 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24047795
DOI: 10.1177/1535370213502627

Genes

PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.PMID 24047795Read ↗

Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.Semantic proximity Read ↗

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