Article
p53 mutations in multiple urothelial carcinomas: a molecular analysis of the development of multiple carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 1997
Goto K, Konomoto T, Hayashi K, Kinukawa N, Naito S, Kumazawa J, Tsuneyoshi M
Abstract excerpt
The purpose of this study is to assess whether the development of synchronous and/or metachronous multifocal urothelial cancers is due to field defect, intraluminal seeding and implantation, or both. We used a series of 42 cases of multiple urothelial cancers. We performed polymerase chain reaction single-strand conformation polymorphism, DNA sequencing, and immunohistochemical studies on p53 gene mutations in 84...
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