Article
HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A. UKHCDO Inhibitor Working Party.
Thrombosis and haemostasis - 1 Feb 1997
Hay C R, Ollier W, Pepper L, Cumming A, Keeney S, Goodeve A C, Colvin B T, Hill F G, Preston F E, Peake I R
Abstract excerpt
The risk of developing factor VIII inhibitor antibodies in haemophilia A may relate both to factor VIII genotype and genes within the HLA complex known to influence immune response. We investigated a cohort of 176 patients with severe haemophilia A and with either high-level inhibitors (> 10BU/ml) or with no history of an inhibitor, stratified according to the presence or absence of the factor VIII gene intron 22...
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