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Article

[Mechanism of acquired antiestrogen resistance and its management in breast cancer].

Nihon rinsho. Japanese journal of clinical medicine - 1 May 1997

Iino Y, Maemura M, Morishita Y

Abstract excerpt

Although non-steroidal antiestrogen, tamoxifen(TAM), has been known to be useful for estrogen receptor(ER)-positive breast cancer, acquired tamoxifen resistance frequently occurs during the treatment. Several factors seem to be responsible for the resistance; decreased level of ER, mutation of ER, agonistic effect of TAM, ovarian steroidogenesis, altered metabolism of TAM, and increased expression level of...

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Identifiers

PMID: 9155167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cross-talk between the oestrogen receptor and the human epidermal growth factor receptor (HER) family : role in resistance to tamoxifen treatment in breast cancerSemantic proximity Read ↗

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