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Article

[DNA topoisomerases targeting anticancer agents and mechanism for acquirement of drug resistance].

Nihon rinsho. Japanese journal of clinical medicine - 1 May 1997

Furukawa M, Harada T, Tanaka T, Kuwano M

Abstract excerpt

DNA topoisomerase(topo) I and II regulate the topological conformation and DNA molecules by catalyzing the concerted breakage of single or double strands. Topo I and II targeting anticancer agents such as camptothecins (CPT-II), epipodophyllotoxins (VP16 and VM26), and amsarcine are widely used in cancer chemotherapy. To enhance their therapeutic efficacies, one should understand how cellular sensitivities to...

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PMID: 9155159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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