Molecular aspects of cancer cell resistance to chemotherapy.

doi:10.1016/j.bcp.2013.02.017

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Article

Molecular aspects of cancer cell resistance to chemotherapy.

Biochemical pharmacology - 1 May 2013

Rebucci Magali, Michiels Carine

Abstract excerpt

Cancer cell resistance to chemotherapy is still a heavy burden that impairs treatment of cancer patients. Both intrinsic and acquired resistance results from the numerous genetic and epigenetic changes occurring in cancer cells. Most of the hallmarks of cancer cells provide general mechanisms to sustain stresses such as the ones induced by chemotherapeutic drugs. Moreover, specific changes in the target bring...

Topics

Animals
Antineoplastic Agents
Apoptosis
Biomarkers, Tumor
DNA Damage
Drug Resistance, Neoplasm
Genes, Tumor Suppressor
Humans
Mutation
Neoplasms
Neoplastic Stem Cells
Oncogenes
Tumor Microenvironment

Source

Open in PubMed

Identifiers

PMID: 23435357
DOI: 10.1016/j.bcp.2013.02.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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