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Cracking the Code: Understanding Cancer’s Defense against Topoisomerase-Active Drugs: A Comprehensive Review

2023-12-18

Abstract excerpt

In recent years, the emergence of cancer drug resistance is one of the crucial tumor hallmarks which is supported by the level of genetic heterogeneity and complexities at cellular levels. Oxidative stress, immune evasion, metabolic reprogramming, overexpression of ABC transporters and stemness are among the several key contributing molecular and cellular response mechanisms. Topo-active drugs, e.g., doxorubicin a...

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Identifiers and source

Literature Corpus work
14fedf90-4b1f-5d93-9439-95d5adad343a
DOI
10.20944/preprints202312.1293.v1
Open publication

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