Article
[Multidrug resistance of cancer cells mediated by ABC superfamily transporters].
Nihon rinsho. Japanese journal of clinical medicine - 1 May 1997
Ueda K
Abstract excerpt
ATP-binding cassette(ABC) superfamily transporters, including P-glycoprotein and MRP, actively transport various structurally dissimilar chemotherapeutic compounds out of cancer cells and confer multidrug resistance. Members of ABC superfamily which may extrude anti-cancer drugs are still expanding, thus the importance of these proteins are further increasing for cancer chemotherapy. Multidrug resistance will be...
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