Article
Bacterial multidrug resistance mediated by a homologue of the human multidrug transporter P-glycoprotein.
IUBMB life - 1 Jan 2000
Konings Wil N, Poelarends Gerrit J
Abstract excerpt
Most ATP-binding cassette (ABC) multidrug transporters known to date are of eukaryotic origin, such as the P-glycoproteins (Pgps) and multidrug resistance-associated proteins (MRPs). Only one well-characterized ABC multidrug transporter, LmrA, is of bacterial origin. On the basis of its structural and functional characteristics, this bacterial protein is classified as a member of the P-glycoprotein cluster of the...
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