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Article

A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis.

Molecular and cellular biology - 1 Jun 1997

Uchiyama M, Galli I, Griffiths D J, Wang T S

Abstract excerpt

A semipermissive growth condition was defined for a Schizosaccharomyces pombe strain carrying a thermosensitive allele of DNA polymerase delta (pol delta ts03). Under this condition, DNA polymerase delta is semidisabled and causes a delay in S-phase progression. Using a genetic strategy, we have isolated a panel of mutants that enter premature mitosis when DNA replication is incomplete but which are not defective...

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Identifiers

PMID: 9154809
DOI: 10.1128/MCB.17.6.3103
PMCID: PMC232163

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