Article
A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis.
Molecular and cellular biology - 1 Jun 1997
Uchiyama M, Galli I, Griffiths D J, Wang T S
Abstract excerpt
A semipermissive growth condition was defined for a Schizosaccharomyces pombe strain carrying a thermosensitive allele of DNA polymerase delta (pol delta ts03). Under this condition, DNA polymerase delta is semidisabled and causes a delay in S-phase progression. Using a genetic strategy, we have...
Topics
- Alleles
- Amino Acid Sequence
- Cell Cycle Proteins
- Checkpoint Kinase 2
- DNA Damage
- DNA Polymerase III
- DNA Replication
- DNA-Directed DNA Polymerase
- Fungal Proteins
- Hydroxyurea
- Mitosis
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis
- Nucleic Acid Synthesis Inhibitors
- Protein Kinases
- Protein Serine-Threonine Kinases
- S Phase