Article
Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function.
Molecular & general genetics : MGG - 1 Jul 1997
McFarlane R J, Carr A M, Price C
Abstract excerpt
Mutation of the essential Schizosaccharomyces pombe rad4/cut5 gene causes sensitivity to UV and ionising radiation at the permissive temperature whilst at the restrictive temperature cells fail to undergo DNA replication but still attempt mitosis owing to a defective S-phase checkpoint response....
Topics
- 4-Nitroquinoline-1-oxide
- Alleles
- DNA Damage
- DNA Replication
- DNA-Binding Proteins
- Fungal Proteins
- G2 Phase
- Gamma Rays
- Genes, Lethal
- Hydroxyurea
- Molecular Mimicry
- Mutagens
- Mutation
- Nucleic Acid Synthesis Inhibitors
- Phenotype
- Ribonucleotide Reductases
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins