Article
Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype.
Annals of neurology - 1 Apr 1995
Nitsch R M, Rebeck G W, Deng M, Richardson U I, Tennis M, Schenk D B, Vigo-Pelfrey C, Lieberburg I, Wurtman R J, Hyman B T
Abstract excerpt
Alzheimer's disease (AD) is characterized by formation in brain of neurofibrillary tangles and of amyloid deposits. The major protein component of the former is tau, while the latter are composed of amyloid beta-peptides (A beta), which are derived by proteolytic cleavage of the amyloid beta-protein precursor (APP). Both tau and various secretory APP derivatives including A beta and APPS are present in human...
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