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Article

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives.

Neurobiology of aging - 1 Mar 2011

Robakis Nikolaos K

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia in the aged population. Most cases are sporadic although a small percent are familial (FAD) linked to genetic mutations. AD is caused by severe neurodegeneration in the hippocampus and neocortical regions of the brain but the cause of this neuronal loss is unclear. A widely discussed theory posits that amyloid depositions of Aβ peptides or their...

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Identifiers

PMID: 20594619
DOI: 10.1016/j.neurobiolaging.2010.05.022
PMCID: PMC3385412

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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