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Article

Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.

The Journal of biological chemistry - 16 Oct 2009

Takemura Miyohiko, Mishima Toshiaki, Wang Yan, Kasahara Jiro, Fukunaga Kohji, Ohashi Kazumasa, Mizuno Kensaku

Abstract excerpt

Actin cytoskeletal remodeling is essential for neurite outgrowth. LIM kinase 1 (LIMK1) regulates actin cytoskeletal remodeling by phosphorylating and inactivating cofilin, an actin filament-disassembling factor. In this study, we investigated the role of LIMK1 in calcium signal-induced neurite outgrowth. The calcium ionophore ionomycin induced LIMK1 activation and cofilin phosphorylation in Neuro-2a neuroblastoma...

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Source

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Identifiers

PMID: 19696021
DOI: 10.1074/jbc.M109.006296
PMCID: PMC2781398

Genes

LIMK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.PMID 19696021Read ↗

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