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Article

Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes.

Biochemistry - 15 Jun 2004

Mansilla Sylvia, Priebe Waldemar, Portugal José

Abstract excerpt

The binding of Sp1 transcription factor to DNA is considered a potential target for small ligands designed to interfere with gene transcription. We attempted to distinguish the direct inhibition of the Sp1-binding to DNA in vivo (cell culture) from more indirect effects due to the network of pathways that modulate cell cycle progression, which may decrease transcription without direct interference with Sp1-DNA...

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PMID: 15182200
DOI: 10.1021/bi036185e

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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