Article
Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiation.
Biochemical and biophysical research communications - 9 Nov 2001
Okamoto Y, Sakata M, Yamamoto T, Nishio Y, Adachi K, Ogura K, Yamaguchi M, Takeda T, Tasaka K, Murata Y
Abstract excerpt
Glucose transporter-1 (GLUT1) is important in placental glucose transport. However, the mechanism of regulation of placental GLUT1 expression remains to be elucidated. We show here that the level of GLUT1 protein in rat choriocarcinoma cells (Rcho-1) decreased during differentiation. To analyze the regulatory mechanism of rat GLUT1 (rGLUT1) gene expression, we transfected rGLUT1 promoter-chloramphenicol...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Differentiation
- Choriocarcinoma
- DNA
- DNA-Binding Proteins
- Electrophoretic Mobility Shift Assay
- Female
- Gene Expression Regulation
- Glucose
- Glucose Transporter Type 1
- Molecular Sequence Data