Article
Peripheral T cell clones from NOD mice specific for GAD65 peptides: lack of islet responsiveness or diabetogenicity.
Journal of autoimmunity - 1 Jun 1996
Schloot N C, Daniel D, Norbury-Glaser M, Wegmann D R
Abstract excerpt
The non-obese diabetic (NOD) mouse develops diabetes as a result of spontaneous T cell mediated destruction of the insulin-producing beta-cells. Tolerization to glutamic acid decarboxylase (GAD65) has been reported to inhibit spontaneous T cell proliferative responses to GAD65 and GAD65 peptides...
Topics
- Amino Acid Sequence
- Animals
- Clone Cells
- Cytokines
- Diabetes Mellitus
- Epitopes
- Female
- Genes, MHC Class I
- Glutamate Decarboxylase
- Immunization, Passive
- Islets of Langerhans
- Lymphokines
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Molecular Sequence Data
- Peptides