Article
Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 1997
Le Fur N, Kelsall S R, Silvers W K, Mintz B
Abstract excerpt
Melanomas tend to become less pigmented in the course of malignant progression. Thus, as proliferation increases, the tumors are decreasingly characterized by the tissue-specific phenotype of normally differentiated melanocytes. To learn whether the decline in melanization is associated with a shift from constitutive to alternative splicing of some pigment gene pre-mRNAs, melanomas were collected from Tyr-SV40E...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.