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Article

Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF.

Nucleic acids research - 15 Jul 2002

Fang Dong, Tsuji Yoshiaki, Setaluri Vijayasaradhi

Abstract excerpt

Tyrosinase (TYR), tyrosinase-related protein-1 (TYRP1/gp75) and dopachrome tautomerase (DCT/TYRP2) belong to a family of melanocyte-specific gene products involved in melanin pigmentation. During melanocyte development expression of tyrosinase family genes is thought to be orchestrated in part by the binding of a shared basic helix-loop-helix transcription factor MITF to the M box, a regulatory element conserved...

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Source

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Identifiers

PMID: 12136092
DOI: 10.1093/nar/gkf424
PMCID: PMC135745

Genes

TYRP1
MITF
TYR
DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF.PMID 12136092Read ↗

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Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein.Semantic proximity Read ↗

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MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expressionSemantic proximity Read ↗

Distinct co-regulation of endogenous versus transfected MITF-dependent tyrosinase promoter.Semantic proximity Read ↗

Gene expression profiling of cultured human NF1 heterozygous (NF1+/-) melanocytes reveals downregulation of a transcriptional cis-regulatory network mediating activation of the melanocyte-specific dopachrome tautomerase (DCT) gene.Semantic proximity Read ↗

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Direct interaction of Sox10 with the promoter of murine Dopachrome Tautomerase (Dct) and synergistic activation of Dct expression with Mitf.Semantic proximity Read ↗

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