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Article

A natural classification of the basic helix-loop-helix class of transcription factors.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 1997

Atchley W R, Fitch W M

Abstract excerpt

A natural (evolutionary) classification is provided for 242 basic helix-loop-helix (bHLH) motif-containing proteins. Phylogenetic analyses of amino acid sequences describe the patterns of evolutionary change within the motif and delimit evolutionary lineages. These evolutionary lineages represent well known functional groups of proteins and can be further arranged into five groups based on binding to DNA at the...

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Identifiers

PMID: 9144210
DOI: 10.1073/pnas.94.10.5172
PMCID: PMC24651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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